Trial | NCT01566578  Report issue

Official Title

A Physiological Study on Downregulation of EGF-receptors in the Skin by Topical Exposition With EGF

  • Phase

    Phase 1

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    24
Investigation of EGF-Receptor Downregulation by topical EGF (dermal cream) exposition.
Study Started
Apr 30
2012
Primary Completion
Nov 30
2012
Anticipated
Study Completion
Nov 30
2012
Anticipated
Last Update
Aug 03
2012
Estimate

Drug Human recombinant epidermal growth factor

topical

Other Placebo cream

Dermal cream without EGF

EGF Cream Experimental

Placebo cream Placebo Comparator

Criteria 

Inclusion Criteria:

Informed consent
Mild to moderate psoriasis (all types) with active plaques on both body sides accessible for biopsy and self product application
EGFR immunohistochemistry score > 5
Male
Age 18-60 years

Exclusion Criteria:

Systemic psoriasis treatment 3 months prior and during the study
Local psoriasis treatment on the investigational sites in the last 30 days or during the study
Known hypersensitivity or allergy to the EGF containing product (Newskin) and/or to Vaseline/10% salicylic acid and/or to local anaesthetics of the amid type
Known or suspected non-compliance to study protocol Coagulopathy or treatment with anticoagulants
History of malignant disease Other clinically relevant concomitant disease state Participation in another investigational drug study in the last 30 days
No Results Posted