Trial | NCT01564680  Report issue

Title

Lornoxicam vs. Paracetamol After Lower Abdominal Surgery
Intravenous Lornoxicam is More Effective Than Paracetamol as a Supplemental Analgesic After Lower Abdominal Surgery; A Randomized Controlled Trial

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    60
Background: The aim of this prospective, randomized, double-blind study is to determine the most effective supplemental analgesic, paracetamol or lornoxicam for postoperative pain relief after lower abdominal surgery.

Methods: Sixty patients scheduled for lower abdominal surgery under general anesthesia were randomly allocated to receive either isotonic saline (Control group), intravenous paracetamol 1 g every 6 h (Paracetamol group) or lornoxicam 16 mg then 8 mg after 12 h (Lornoxicam group). Additionally pain was treated postoperatively using morphine patient-controlled analgesia. Postoperative pain scores measured by the verbal pain score (VPS), morphine consumption and the incidence of side effects were measured at 1, 2, 4, 8, 12 and 24 hours postoperatively.
Study Started
Mar 31
2009
Primary Completion
Mar 31
2011
Study Completion
Mar 31
2011
Last Update
Mar 28
2012
Estimate

Other placebo

normal saline

  • Other names: 0.9 N sodium chloride

Drug Paracetamol

IV paracetamol infusion

  • Other names: perfalgan

Drug Lornoxicam

16 mg at skin closure and 8 mg 12 hours postoperative

  • Other names: xefo

Lornoxicam Experimental

Lornoxicam 16 mg will be given at skin closure and 8 mg will be given 12 hours postoperatively

Control Placebo Comparator

Patients will receive normal saline at skin closure, at 6, 12, 18 hours postoperatively.

Paracetamol Experimental

1 gm of paracetamol will be given at skin closure, 6, 12, 18 hours postoperatively

Criteria 

Inclusion Criteria:

lower abdominal surgery

Exclusion Criteria:

body weight more than 150% of their ideal body weight
history of significant cardiac, pulmonary, renal, hepatic or hematological disease; chronic drug or alcohol abuse; hypersensitivity to any of the studied drugs; bronchial asthma; gastritis or peptic ulcer; and pregnancy
patients who received any analgesic drug a day before surgery
No Results Posted