Trial | NCT01556802  Report issue

Title

Use of Minocicline in Patients With Stroke
Effect of Minocicline Use in Less Neurologic Sequels in Patients With Stroke

  • Phase

    Phase 1

  • Study Type

    Interventional

  • Status

    Unknown status

  • Intervention/Treatment

    minocycline ...

  • Study Participants

    134
The investigators will evaluate the National Institute of Health Stroke Scale/Score (NIHSS)in patients with stroke, and then give Minocycline 100mg po every 12 hours or placebo for five days, then perform periodic evaluations to determine the status and degree of neurological sequelae developed.
Study Started
Oct 31
2011
Primary Completion
Nov 30
2011
Study Completion
Jan 31
2013
Anticipated
Last Update
Mar 16
2012
Estimate

Drug Minocicline

Minocicline 100mg oral twice a day for 5 days

Drug Placebo

Pills with vegetable fibers one pill oral twice a day for five days

Minocicline Experimental

minocicline 100mg oral twice a day for 5 days

Placebo Placebo Comparator

Pills filled with vegetal fiber with similar presentation of the drug. Given one pill oral twice a day for five days

Criteria 

Inclusion Criteria:

NIHSS scale greater than 5
Onset of symptoms less than 24 hours
normal Cranial Tomography(CT)
CT evidence of cerebral ischemia
Acceptance of study entry

Exclusion Criteria:

Hemorrhagic cerebrovascular disease
Other neurological diseases
Concomitant structural damage
History of neurosurgery
Known allergy to tetracyclines
Concomitant infectious diseases requiring antibiotic treatment.
History of Stroke
Women pregnant or breast-feeding
No Results Posted