Trial | NCT01556698  Report issue

Title

Study of NVN1000 Topical Gel and Topical Gel Vehicle in the Treatment of Moderate to Severe Acne Vulgaris
Single-Center, Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Comparison, Proof of Concept Study Comparing the Tolerability, Safety and Efficacy of NVN1000 Topical Gel Gel Vehicle in the Treatment of Moderate to Severe Acne

  • Phase

    Phase 1/Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    nvn1000 ...

  • Study Participants

    70
The primary objective of this study is to compare the tolerability, safety and efficacy of NVN1000 Topical Gel and Topical Gel Vehicle in the treatment of subjects with moderate to severe acne vulgaris.
The objective of this study is to evaluate the tolerability, safety and efficacy of once daily application of NVN1000 Topical Gel for 8 weeks in comparison with its vehicle in subjects with moderate to severe acne.
Study Started
Jul 31
2011
Primary Completion
Dec 31
2011
Study Completion
Dec 31
2011
Last Update
Nov 19
2018

Drug NVN1000

  • Other names: Nitric Oxide 0.3%

Drug Vehicle

Placebo

  • Other names: Vehicle Comparator

NVN1000 Gel Experimental

NVN1000 Gel topically applied one daily at bedtime for 8 weeks

Vehicle Gel Placebo Comparator

Vehicle Gel topically applied once daily at bedtime for 8 weeks

Criteria 

Inclusion Criteria:

Baseline IGA score of moderate (3) or severe (4)
Minimum of 20 but no more than 40 facial inflammatory lesions
Minimum of 20 but not more than 60 facial non-inflammatory lesions
No more than 2 facial nodules

Exclusion Criteria:

Dermatological conditions on the face that could interfere with clinical evaluations
Underlying disease(s) or some other dermatological condition of the face that requires the use of interfering topical or systemic therapy or makes evaluations and lesion count inconclusive
History of experiencing significant burning or stinging when applying any facial treatment
Female subjects, if they are pregnant,nursing mothers, or planning to become pregnant during the study
Have used estrogens or oral contraceptives for less than 90 days immediately preceding the Baseline visit, discontinued use of estrogens or oral contraceptives less than 90 days prior to Baseline,or planning to begin or discontinue use of this therapy during the treatment period
Have used medications and/or vitamins which are reported to exacerbate acne during the 180 days immediately preceding the Baseline visit
Use concomitantly over-the-counter (OTC) products that contain ingredients such as benzoyl peroxide,salicylic acid,alpha-hydroxy acid,retinol or glycolic acids
Have not undergone the specified washouts for topical preparations,systemic medications and procedures noted in the protocol
No Results Posted