Trial | NCT01481870  Report issue

Title

Comparison of Sequential Therapies With Sunitinib and Sorafenib in Advanced Renal Cell Carcinoma
Randomized Comparison of Sequential Therapies With Sunitinib and Sorafenib in Advanced Renal Cell Carcinoma

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    120
The clinical benefits of sunitinib and sorafenib have been demonstrated in patients with cytokine-refractory metastatic renal cell carcinoma. Sunitinib has also been shown to improve progression free survival and overall survival in a comparative study with interferon-alpha. When sunitinib is used as first-line molecular-targeted therapy, switching to sorafenib is one of the treatment options after disease progression. Reversely, when sorafenib is used as first-line molecular-targeted therapy, sunitinib is used as second-line therapy. The goal of cancer treatment is cure, and if cure is not possible, it is to prolong survival. In this study, sunitinib or sorafenib will be administered as first-line molecular-targeted therapy and treatment switched to the other test drug, sorafenib or sunitinib, when disease progression is detected to assess which treatment sequence produces longer progression free survival and offers a better safety profile (causing fewer adverse events). The purpose of this trial is to compare progression free survival of first line sunitinib versus sorafenib, and that of two treatment sequences, i.e. sunitinib followed by sorafenib versus sorafenib followed by sunitinib.
Study Started
Jan 31
2010
Primary Completion
Jul 31
2013
Anticipated
Study Completion
Dec 31
2015
Anticipated
Last Update
Feb 25
2013
Estimate

Drug Sorafenib-sunitinib

sorafenib 400mg b.i.d. followed by sunitinib treatment when progression is observed

Drug Sunitinib-sorafenib

sunitinib 50mg q.d. 4 weeks on two weeks off followed by sorafenib treatment when progression is observed

Sorafenib-sunitinib Active Comparator

Sorafenib is first line treatment followed by sunitinib.

Sunitinib-sorafenib Active Comparator

Sunitinib is first line treatment followed by sorafenib.

Criteria 

Inclusion Criteria:

Age: 20-80 years old, both inclusive
ECOG performance status of 0, 1, or 2
MSKCC risk of favorable or intermediate
Histologically confirmed renal cell carcinoma
No ischemic heart disease

Laboratory findings meet the following criteria:

Respiratory function: %VC, 80% and FEV1.0,70%
Hematology: white blood cell count4,000/mm3, platelet count100,000/mm3
Clinical chemistry: GOT and GPT within the normal range of each medical institution; total bilirubin <1.5 x ULN
Serum creatinin <2.0mg/dl, blood urea nitrogen (BUN) <25mg/dl
Echocardiographic estimation of left ventricular ejection fraction is higher than the lower limit of reference range of each medical institution.

Exclusion Criteria:

History of any other malignancy
Central nervous system metastases. However, patients who remain asymptomatic, have no new or enlarging lesion in the CNS within 6 months of enrollment in this study, and require no corticosteroids may be enrolled.
History of cardiac infarction, unstable angina, congestive heart failure, or symptomatic peripheral vascular disease within 12 months of enrollment
History of cerebrovascular disorder including transient ischemic attack (TIA)
Pregnancy or possible pregnancy at any time during the study
Ongoing grade 2 adverse event prior treatment
Prior treatment with any anticancer therapy including cytokine therapy such as interferon-alpha and interleukin-2
Prior treatment with mTOR inhibitor
Prior treatment with sunitinib or sorafenib
Treatment with an test drug in a clinical research within 4 weeks of enrollment in this study
No Results Posted