Trial | NCT01477736  Report issue

Official Title

A Comparison Study of Oxybutynin and Botulinum Toxin for Neurogenic Detrusor Overactivity

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    68
The purpose of this study is to compare the effects of oral oxybutynin and intradetrusor injections of botulinum toxin type A on urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity following spinal cord injury.
Study Started
Jan 31
2009
Primary Completion
Nov 30
2010
Study Completion
Nov 30
2010
Last Update
Nov 22
2011
Estimate

Drug Oxybutynin

5 mg of immediate-release oxybutynin orally 3 times daily

Drug Botulinum toxin A

300 U intradetrusor injection

Botulinum toxin A Active Comparator

oxybutynin Active Comparator

Criteria 

Inclusion Criteria:

Spinal cord injury
Detrusor overactivity
Age over 18 years
Spinal cord injury at least 12 months duration
Undergoing regular clean intermittent catheterisation

Exclusion Criteria:

Pregnancy
Desire to become pregnant during the study period
Breastfeeding
Blood coagulation disorder
Neuromuscular transmission disorder
Use of any intravesical pharmacologic agents
Previous use of botulinum toxin A
No Results Posted