Title
The Effect of Honey on Xerostomia and Oral Mucositis
A Randomized Control Trial for the Effect of Honey on Radiotherapy Induced Xerostomia and Oral Mucositis in Patients With Head and Neck Cancers
Phase
Phase 2Lead Sponsor
Cyprus University of TechnologyStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Head and Neck CancerIntervention/Treatment
honey ...Study Participants
72The purpose of this study is to determine whether the use of pure honey will help in the treatment of radiation induced xerostomia and oral mucositis (symptom management)
Radiation-induced mucositis is a normal acute side effect of radiotherapy treatment. Exposure of ionising radiation to oral, pharyngeal and laryngeal mucosa gives rise to radiation epithelitis towards the second and third weeks of conventional fractionated radiotherapy. Likewise, salivary flow may decrease by approximately 50% during the first week of radiotherapy and upwards of 80% by the seventh week of treatment. Acute radiation-induced xerostomia is associated with inflammatory reaction. The study will include an intervention and a control group, one receiving honey prior and after the radiotherapy and the other group not receiving honey at all.
The patients in the intervention group will receive honey mouthwash 15 minutes before the radiotherapy session, 15 minutes after and 6 hours after the radiotherapy session
Saline rinses 15 minutes before radiotherapy, 15 minutes after, and 6 hours after radiotherapy
The patients will receive honey mouthwash rinses
The patients in this group will receive saline rinses
Inclusion Criteria: Patients who receive radiotherapy (RT) to the oral cavity will be included in the study. Patients with a confirmed histologic diagnosis of head and neck cancer referred to non-palliative radiotherapy will enter into this trial. aged over 18 receiving radiotherapy for at least four weeks Exclusion Criteria: Allergic to honey confirmed and medically treated diabetes mellitus
