Trial | NCT01424735  Report issue

Title

TLR-9 Antagonism in Steroid Resistant Optic Neuritis
Outcomes of TLR-9 Antagonism in Steroid Resistant Optic Neuritis; A Pilot Study

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    8
Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9 has been shown to play a role in the pathogenesis of optic neuritis. This small case series aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9 antagonism)play any role in improving the visual function in such patients.
Study Started
Jul 31
2006
Primary Completion
Jan 31
2010
Study Completion
May 31
2010
Last Update
Aug 29
2011
Estimate

Drug Mycobacterium w.(Mw)-freeze dried extract 0.5ml

0.5 ml of Mw in 500ml 0.9% normal saline administered over two hours as an infusion. 2ml(4mg/ml) of dexamethasone administered two hours prior to Mw administration

  • Other names: IMMUVAC

Mw. Experimental

Administration of immunomodulator Mw.

Criteria 

Inclusion Criteria:

Unilateral Steroid Resistant Optic Neuritis

Exclusion Criteria:

bilateral optic neuritis
Associated Systemic disease
Prior treatment received
No Results Posted