Trial | NCT01414647  Report issue

Title

The Health Effect of Diet Rich in Nordic Berries
The Effect of Diet Rich in Nordic Berries on Gut Microbiota, Glucose and Lipid Metabolism and Metabolism on Fenolic Compounds

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    56
Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures. The findings regarding the possible decrease of low-grade inflammation are existing also in humans. Low-grade inflammation has been suggested to be a mechanistic link between obesity and its consequences on cardiometabolic health. The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers.
Berries are traditionally an important part of the Nordic diet. About 50 different berries are grown in the northern region, and about half of them are edible. Phenolic compounds are one of the most diverse group of secondary metabolites present in edible plants, and berries are especially rich in them. Flavonoids, phenolic acids, lignans and complex phenolic polymers (polymeric tannins) are typical for berries. Phenolic compounds are reported to have a variety of beneficial biological properties. They are potent antioxidants, and exhibit various other physiological activities including anti-inflammatory, antimicrobial, antiallergic, anticarcinogenic and antihypertensive activities. Epidemiological studies indicate that diet rich in phenolic compound correlates with lower risk of cancer and cardiovascular disease.

The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers and gene expression profile in peripheral blood mononuclear cells (PBMCs) in subjects with features of metabolic syndrome.

Randomized, controlled clinical intervention including 4 wk run-in period, 8 wk dietary intervention and 4 wk recovery period was conducted.
Study Started
Jan 31
2006
Primary Completion
Dec 31
2006
Study Completion
Mar 31
2010
Last Update
May 17
2018

Dietary Supplement 300 g of strawberry, raspberry and cloudberry

100 g of strawberry puree, 100 g of frozen raspberries and 100 g frozen cloudberries were concumed daily for 8 weeks. Bilberry consumption was restricted.

Dietary Supplement 400 g of bilberry

Equivalent amount to 400 g of fresh bilberries were consumed as 40 g of dried bilberries and as 200 g of frozen bilberries. Restriction of use of strawberries, raspberries and cloudberries were set.

Other Control diet

Control diet, ie. habitual diet with restriction of berry consumption was consumed for eight weeks

  • Other names: Diet with restricted consumption of berries.

SRC Experimental

Strawberry, raspberry and cloudberry intervention for 8 weeks

BB Experimental

Bilberry intervention for 8 weeks

C Experimental

Control diet with restricted berry consumption

Criteria 

Inclusion Criteria:

overweight (BMI 26-39 kg/m2), and two of the following:
elevated fasting plasma glucose in the absence of diabetes (5.6-6.9 mmol/l)
abnormal serum lipid concentration: fasting serum triglyceride concentration >1.7 mmol/L, fasting serum HDL cholesterol <1.0 mmol/L (males) or <1.3 mmol/L (females))
waist circumference >102 cm (males) or >88 cm (females)
blood pressure >130/85 mmHg

Exclusion Criteria:

chronic diseases
use of lipid lowering medication
No Results Posted