Trial | NCT01384812  Report issue

Title

Prostaglandin E2 in Migraine Suffers Without Aura.
Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of Prostaglandin E2 in Migraine Suffers Without Aura.

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    12
The hypothesis of this study is that Prostaglandin E2 (PGE2) induces headache and dilatation of brain vessels in migraine patients without aura.
Study Started
Sep 30
2010
Primary Completion
Jul 31
2011
Study Completion
Jul 31
2011
Last Update
Nov 09
2011
Estimate

Drug dinoprostone

intravenous injection 0.4 μgr/kg/min for 25 min

  • Other names: Prostin E2

Drug isoton sodium chloride

intravenous injection for 25 min

  • Other names: placebo

Isoton sodium chloride Placebo Comparator

Prostin E2 (dinoprostone) Active Comparator

Criteria 

Inclusion Criteria:

Patients with migraine without aura

Exclusion Criteria:

Tension type headache more than x 3 per month
Other forms for primary headache
Headache 24 h before the day of the investigation
Migraine 48 h before the day of the investigation
Hypertension
Hypotension
Pregnant/nursing
Daily intake of medication (except oral contraceptives and migraine rescue medicine during migraine attack)
Cardiovascular or central nervous system (CNS) disease
Drug/alcohol abuse
Psychiatric disease
Asthma or any other lung diseases
No Results Posted