Clinical Drug Experience Knowledgebase

Criteria

Inclusion Criteria:

aged from 18 to 70 years old, male or female;
histologically or cytologically proven advanced malignant solid tumors;
cancer patients after conventional treatment failure and lack of effective treatment, or patients refusing effective treatment of existing practices;
patients receiving the last treatment (chemotherapy, radiotherapy, biological therapy, targeted therapy, or other study drugs) for at least 4 weeks;
expected survival time>3 months;
ECOG score 0-1

Exclusion Criteria:

viral activity in patients
allergic to drugs or excipients;
hypersensitivity to paclitaxel injection patients;
HIV antibody positive, or suffering from other acquired and congenital immune deficiency disease, or history of organ transplantation;
neutrophil count <1.5 × 109 / L, platelets <100 × 109 / L, or hemoglobin <90g / L;
normal serum creatinine higher than 1.5 times the upper limit of reference range or the muscle of liver clearance <60ml/min;
no case of liver ALT or AST> 2.5 times the upper limit of normal, or liver metastases than normal under the ALT or AST 5 times upper limit of reference range;
fever or body temperature above 38 ℃ can be clinically significant impact on clinical trials of active infection;
medications failed to control hypertension (systolic pressure is over 160 mmHg or diastolic pressure over 100mmHg);
significant cardiovascular abnormalities (such as myocardial infarction, superior vena cava syndrome), or clinically significant arrhythmias (such as long QT syndrome, Corrected QTc not be measured or ≧ 480 ms);
calcium, potassium, magnesium ions below the lower limit of normal;
> I-level peripheral neuropathy
Prior to the toxicity of anticancer therapy has not been restored or not from the surgery before full recovery;
bone metastases for the primary lesion of palliative radiotherapy;
any clinical problems can not control (such as the serious mental, neurological, cardiovascular, respiratory and other diseases);
a tumor metastasis, or a variety of mental disorders center; no history of asthma;
pregnancy or breast-feeding women