Trial | NCT01268709  Report issue

Title

Effect of Doxepin and Nortriptyline on Irritable Bowel Syndrome

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    None
The objective of this randomized triple blind controlled trial is to compare the effects of Doxepin and Nortriptyline on diarrhea predominant irritable bowel syndrome. In this stuy, 75 patients with IBS are randomly assigned to receive Doxepin , Nortriptyline or placebo, a tablet per day, orally, for two months. Abdominal pain, mucus in the stool, incomplete evacuation, and bloating are measured and compared between groups at the baseline and one and two month after the intervention.
Study Started
Dec 30
2010
Last Update
Dec 31
2010
Estimate

Drug Doxepin

Drug Nortriptyline

Drug placebo

doxepin Active Comparator

nortriptyline Active Comparator

placebo Placebo Comparator

Criteria 

Inclusion Criteria:

Presence of diarrhea predominant irritable bowel syndrome according to ROME criteria

Exclusion Criteria:

Gastrointestinal bleeding
More than 5% weight loss in the last 6 months
Presence of any finding in favor of organic disorders in the lab tests or organic disorder in colonoscopy of high risk patients
No Results Posted