Trial | NCT01141803  Report issue

Title

Effect of Apple and Apple Pomace on Inflammation and Cholesterol Metabolism in Healthy Overweight
Isafruit: Nutrigenomics in Overweight

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    apple ...

  • Study Participants

    37
The investigators will assess the protective and antiinflammatory effects of processed fruit and fruit fibre in overweight subjects with signs of metabolic syndrome. A single-blinded parallel study is conducted to investigate the protective effects of fruit fibre on colonic epithelium. Relevant signalling pathways related to cholesterol metabolism, vascular inflammation, oxidative defence, apoptosis and sterol metabolism will be targeted. Volunteers are randomly assigned one of three groups. They are instructed to follow a polyphenol and pectin restricted diet for six weeks. The last four weeks in this six week period, the restricted diet is supplemented with whole apples (550g/day), apple pomace (22g/day) or nothing. Blood, urine, faecal samples and colon biopsies are collected before and after the four weeks intervention period.
Study Started
Jul 31
2008
Primary Completion
Dec 31
2009
Study Completion
Oct 31
2010
Last Update
Jul 20
2016
Estimate

Dietary Supplement Apples

550g of apples/day

Dietary Supplement Apple pomace

22g apple pomace/day

control No Intervention

Apples Active Comparator

Apple pomace Active Comparator

Criteria 

Inclusion Criteria:

Healthy
BMI over 30
No daily medication
Not strenuous exercise > 10hours/week
No blood donation 3 months before or during the study

Exclusion Criteria:

Smoking
Simultaneous participation in other research projects
Use of any dietary supplements
No Results Posted