Title
Hyperbaric Oxygen Therapy for Acute Domestic Carbon Monoxide (CO) Poisoning
Phase 3 Study of Hyperbaric Oxygen Therapy in Non-Comatose Patients With Acute Domestic Carbon Monoxide Poisoning
Phase
Phase 3Lead Sponsor
University of VersaillesStudy Type
InterventionalStatus
TerminatedIndication/Condition
Carbon Monoxide PoisoningIntervention/Treatment
Hyperbaric oxygen therapy normobaric oxygen therapyStudy Participants
179Carbon monoxide poisoning still places a burden on the healthcare system worldwide. While oxygen therapy is the cornerstone treatment, the role and practical modalities of hyperbaric oxygen therapy (HBO) remain controversial. This study aimed at comparing one session of HBO at 2 absolute atmosphere followed by 4 hours of normobaric oxygen therapy to 6 hours of normobaric oxygen therapy in adult victims of acute domestic carbon monoxide poisoning and without coma.
Hyperbaric oxygen therapy was delivered in a hyperbaric chamber, pressurized at 2 absolute atmosphere (1 hour plateau) and the patient breathed high oxygen concentration via a full face mask followed by 4 hours of normobaric oxygen therapy
oxygen therapy was delivered via a full face mask at high flow to achieve 100% of inspired oxygen fraction
Hyperbaric oxygen therapy at 2 absolute atmosphere (1-hour plateau) followed by 4 hours of normobaric oxygen therapy
6 hours course of normobaric oxygen therapy via a face full mask
Inclusion Criteria: patients older than 15 years of age admitted for domestic CO poisoning within 12 hours after the end of CO exposure. had transient loss of consciousness (syncope, malaise) carboxyhemoglobin level at presentation >10% or 5%, in smokers and non-smokers, respectively. Exclusion Criteria: poisoning by more than one compound (e.g., CO plus a drug or CO plus other toxic gases such as those found in fire smoke suicide attempt pregnancy coma contraindications to HBO (circulatory collapse or pneumothorax) technical obstacles to HBO non domestic CO poisoning difficulty in determining whether the patient experienced initial loss of consciousness or initial coma consent refusal.
