Trial | NCT01057680  Report issue

Title

Effectiveness of Creatine Supplementation and Exercise on Muscle and Bone
Potential of Resistance-Exercise and Creatine Supplementation on Aging Musculoskeletal Health

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    90
As we age, we experience a reduction in muscle and bone which inevitably decreases strength and the ability to perform tasks of daily living such as gardening, carrying groceries, and climbing stairs. Health costs associated with aging muscle and bone loss are in the billions of dollars. With the projected increase in life expectancy, the incidence of muscle and bone loss will rise and further drain the healthcare system, with greater need for hospitalization, treatment, and rehabilitation. Without effective strategies to counteract aging muscle and bone loss, we may face a healthcare crisis in the future. Creatine, a compound found in red meat and seafood, increases creatine phosphate stores in muscle, providing increased energy during high-intensity exercise. Short-term (i.e. 3-4 months) resistance-exercise and supplementation with creatine, have been shown to have a favorable effect on properties of aging muscle and bone. However, the longer-term (i.e. 1 year) effects of these interventions are unknown. Therefore, the purpose of this innovative research is to determine the longer-term effects of resistance-exercise and creatine supplementation (0.1g•kg-1) in older adults. The primary dependent variables to be assessed will include muscle hypertrophy, bone mineral and bone geometry, strength, and urinary and blood indicators of liver and kidney function. This innovative, multidisciplinary research will help contribute to the successful pursuit of prolonged independent living by improving aging musculoskeletal health for older Saskatchewan adults. Saskatchewan provides a relevant setting for this research, given the higher percentage of older adults (15%), compared to the national average (12%).

We hypothesize that creatine supplementation will increase muscle mass, strength, and bone mineral density more than placebo.
Study Started
Jan 31
2010
Primary Completion
Feb 29
2012
Study Completion
Feb 29
2012
Last Update
Dec 27
2012
Estimate

Dietary Supplement creatine monohydrate

Powder, 0.1 g per day, 12 months

  • Other names: Rivalus

Dietary Supplement sugar placebo

powder, 0.1 g/day, 12 months

creatine Experimental

This arm will involve creatine supplementation 0.1 g per kg body mass per day while participating in a resistance training program (1 hour per day, 3 days per week).

Sugar Placebo Comparator

This arm will involve placebo (maltodextrin) given every day while the participant does a resistance training program (1 hour per day, 3 days per week).

Criteria 

Inclusion Criteria:

greater than or equal to 50 years of age
males or postmenopausal females
not currently participating in resistance training

Exclusion Criteria:

pre-existing kidney abnormalities
previous fragility fractures
history of taking medications that affect bone mineral density in the past year including bisphosphonates, parathyroid hormone, calcitonin, hormone replacement therapy, or corticosteroids (i.e. within the past year)
suffer from severe osteoarthritis
have taken creatine supplementation within the past 6 months
No Results Posted