Trial | NCT01052870  Report issue

Title

Association of Polymorphisms in the Androgen Receptor Gene and Finasteride Response in Women With Androgenetic Alopecia
Study Evaluating the Association of CAG Repeat Polymorphisms and Finasteride Response in Women With Androgenetic Alopecia

  • Phase

    Phase 1

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    12
Previous studies of finasteride treatment in women with hair loss have failed to show positive results, yet, some women have responded anecdotally. Given that polymorphisms of the androgen receptor gene which confer androgen sensitivity impact male response to finasteride therapy, it was hypothesized that the same polymorphism in women may identify the group that will respond. This study is designed to test the impact of finasteride therapy on hair loss in postmenopausal women.
Androgen sensitivity in the cell is determined by the number of Cytosine-Adenine-Guanine repeats in the Androgen Receptor gene. Lower CAG repeats have been associated in previous studies with androgenic conditions such as acne, hirsutism and hair loss in men and women. Keeping this in mind, we tested women with hair loss in the frontal or vertex area, for their AR genotype. Patients were randomized to placebo or 1 mg finasteride therapy for 6 months. Global photographs and 2 tatooed areas of 1cm2 each were measured monthly to assess global appearance and hair counts for medication impact.
Study Started
Dec 31
2008
Primary Completion
Dec 31
2009
Study Completion
Dec 31
2009
Last Update
Jan 20
2010
Estimate

Drug Finasteride

Effect of 1 mg finasteride on women with androgenetic alopecia depending on their AR gene polymorphism (androgen sensitivity)

androgen receptor gene polymorphism Other

Medication response will be assessed according to androgen receptor genotype

finasteride Active Comparator

medication for treating androgenetic alopecia in women

Criteria 

Inclusion Criteria:

women with hair loss

Exclusion Criteria:

pre menopausal,
metabolic or medication or non-androgenetic causes of hair loss,
diffuse hair loss
No Results Posted