Trial | NCT01024140  Report issue

Official Title

Open Trial of Escitalopram Treatment for Male Subjects With Posttraumatic Stress Disorder

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    16
The primary aim of this pilot study is to test the efficacy of the selective serotonin re-uptake inhibitor, Escitalopram, in the treatment of posttraumatic stress disorder (PTSD) in an open clinical trial.

A secondary aim is to determine whether treatment with escitalopram increases plasma allopregnanolone levels in patients with PTSD and if increases in allopregnanolone levels are correlated with treatment efficacy.
Study Started
Feb 28
2003
Primary Completion
Dec 31
2004
Study Completion
Dec 31
2004
Last Update
Dec 02
2009
Estimate

Drug Escitalopram

Subjects were started on 5mg escitalopram. Medication was increased as tolerated in weekly 2.5, 5 or 10 mg increments, until a maximally tolerated dosage or a clinical response was achieved. The final dosage ranged from 5 to 20 mg/day.

  • Other names: Lexapro

Escitalopram Experimental

Flexible dose (5-20mg/day) of escitalopram monotherapy.

Criteria 

Inclusion Criteria:

Current DSM-IV TR PTSD and a score > 40 on the CAPS, as a result of a traumatic event that occurred at least 6 months prior to evaluation.

Exclusion Criteria:

Lifetime history of bipolar or any psychiatric disorder with psychotic features.
Prominent suicidal or homicidal ideation.
History of alcohol abuse/dependence within the past 3 months.
History of drug abuse/dependence within the past 6 months.
Subjects who plan to start a new form of psychotherapy during the protocol.
History of sleep apnea, neurological disorder and/or current systemic illness affecting central nervous system function.
History of myocardial infarction in the past year.
Subjects on antipsychotic medications, systemic steroid medication, antidepressants, mood stabilizers, antianxiety medication, or benzodiazepines within the past 2 weeks.
Use of Citalopram or Escitalopram within the past 6 months.
No Results Posted