Trial | NCT01009658  Report issue

Title

MSG and Gastrointestinal Motility
Effect of Monosodium Glutamate on Upper Gastrointestinal Tract Motility

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    40
The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).
Amino acids such as monosodium glutamate are known to stimulate both endocrine and exocrine secretion. In addition, there is a report that oral intake of glutamate evokes the activation of vagal afferent nerves in the rat. Thus, such amino acids are thought to be influential in the process of digestion and absorption.

. To investigate the effect of monosodium glutamate on gastrointestinal motility, we planned a single-blind randomized study. The participants will take either monosodium glutamate or sodium chloride before the first examination of upper GI motility and the other agent before the second examination. The order of intake will be randomized by the envelope method.
Study Started
Dec 31
2009
Primary Completion
Mar 31
2015
Last Update
Mar 26
2015
Estimate

Dietary Supplement Monosodium glutamate

Oral intake of 2.0 g of monosodium glutamate on the examination day and 0.6 g of sodium chloride on the other examination day.

Dietary Supplement Sodium chloride

Oral intake of 0.6 g of sodium chloride on the examination day and 2.0 g of monosodium glutamate on the other examination day.

MSG first Active Comparator

NaCl first Placebo Comparator

Criteria 

Inclusion Criteria:

Healthy subjects
Must not have digestive symptoms
Must not eat within six hours of study participation

Exclusion Criteria:

Regular medications for the gastrointestinal tract
Previous Helicobacter pylori infection
Previous abdominal surgery
No Results Posted