Clinical Drug Experience Knowledgebase

Criteria

Inclusion Criteria:

age between 19 and 55 years
relapsing course of multiple sclerosis (relapsing-remitting or secondary progressive MS with relapses
duration of the disease of at least 1 year
no disease modifying therapy or unchanged immunomodulatory therapy for the last 3 months
at least 2 documented relapses during the last 24 months with the last relapse within the last 12 months

Exclusion Criteria:

pregnancy or period of breastfeeding or missing adequate contraceptive protection for female premenopausal patients
relapse in the last month prior enrolment
treatment with steroids in the last 30 days
previous treatment with mitoxantroneduring the last year
previous treatment with cyclophosphamide or other intensive immunosuppression, total irradiation
treatment with glatiramer acetate, azathioprine, IVIG or any other immunosuppressive or immunomodulatory drug apart from interferon-beta in the 6 months prior to enrolment
cardiac insufficiency (NYHA III/IV), cardiomyopathy, significant cardiac dysrhythmia requiring treatment, instable or advanced ischemic heart disease (CCS III or IV), malignant hypertension
diabetes mellitus and other autoimmune diseases
history of renal insufficiency
stay in tropical areas during the last 3 months
eosinophilia in the blood (> 0,45 billion/l)
concurrent systemic infections