Trial | NCT01005927  Report issue

Official Title

Fructooligosaccharide and Calcium Absorption in Adolescent Girls

  • Phase

    Phase 1/Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    26
Fructooligosaccharides (FOS) are believed to have positive effects on calcium absorption and bone accrual during growth. This study aims to see whether the addition of fiber in the form of FOS to a calcium-containing beverage will increase calcium absorption. During two clinical visits, participants will receive a beverage containing a small amount of calcium, supplemented with either no dietary fiber or a small amount of fiber. Height, weight, bone density and geometry, calcium absorption, and physical fitness will be measured. The effects of this fiber intervention may provide support for improving bone health with minimal fiber supplementation.
Study Started
Jan 31
2009
Primary Completion
Jun 30
2009
Study Completion
Jun 30
2009
Last Update
May 07
2018

Dietary Supplement Fructooligosaccharide

Zero or 3 g of a fructooligosaccharide will be administered in a beverage containing 300 mg total calcium as well as 15 mg 44Ca (calcium carbonate). Participants will be given one of the above beverages in addition to intravenously receiving 5 mg 43Ca (calcium chloride)in 10 ml saline.

  • Other names: Fiber and Calcium

No Fructooligosaccharide Placebo Comparator

0 g fructooligosaccharide added to calcium-containing beverage

3 g Fructooligosaccharide Active Comparator

3 g fructooligosaccharide added to calcium-containing beverage

Criteria 

Inclusion Criteria:

Female
Calcium intake of 900-1300 mg/d
Generally healthy

Exclusion Criteria:

Male
BMI > 90th percentile for age
Takes medication that influences calcium metabolism
Any disorder of calcium or bone homeostasis (hypercalcemia, Paget's Disease)
Smoking, illegal drug consumption
Any gastrointestinal disease (Crohn's Disease, Celiac Disease, Inflammatory Bowel Disease)
No Results Posted