Trial | NCT00997750  Report issue

Title

Efficacy and Safety of Lornoxicam in Patients With Acute Coronary Syndrome
Prospective Randomized Double-center Study of Nonsteroidal Antinflammatory Drug Lornoxicam in Patients With Acute Coronary Syndrome Without Persistent ST- Segment Elevation

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    lornoxicam ...

  • Study Participants

    85
The purpose of this study is to determine whether nonsteroidal antiinflammatory drug lornoxicam in combination with low dose aspirin (100mg/day) is effective and safe in patients with Acute Coronary Syndrome without persistent ST-segment elevation.
Nonsteroidal Antiinflammatory drugs (NSAIDs) are the most frequently prescribed drugs in the world. There are a lot of controversial information published during recent years about NSAID cardiosafety. It is still unclear do NSAIDs develop cardioprotective or cardiotoxic effects in acute and chronic heart disease patients. Aim of the study was to investigate safety and efficacy of Lornoxicam, nonselective COX-inhibitor, in patients with acute coronary syndrome without ST-segment elevation (NSTEACS) and to evaluate the influence of Lornoxicam on C-reactive protein (CRP) and IL-6, IL-10 levels.
Study Started
Mar 31
2007
Primary Completion
Dec 31
2008
Study Completion
Jun 30
2009
Last Update
Oct 19
2009
Estimate

Drug Lornoxicam

lornoxicam 8mg/day and 12mg/day for 15 days

  • Other names: Xefocam

Lornoxicam Experimental

Lornoxicam 8mg/day and 12mg/day for 15 days

Criteria 

Inclusion Criteria:

Unstable angina verified during first 48 hours after admitting to the hospital or
Acute Miocardial infarction without St-segment elevation verified during first 48 hours after admitting to the hospital

Exclusion Criteria:

High risk of bleeding of any location
Any kind of acute and active inflammatory process (excluding acute coronary syndrome)
Aspirin or NSAID Intolerability
No informed consent
Acute peptic stomach or duodenum ulcer
Acute or chronic renal failure (serum creatinin >300 mmol/l)
Acute cerebrovascular bleeding
No Results Posted