Trial | NCT00987142  Report issue

Title

Trial To Assess Efficacy Of A Chimeric Skin In Patients With Epidermolysys Bullosa
A Comparative Open-Label Multicentre Clinical Trial To Assess The Efficacy And Safety Of A New Therapy With Cultured Chimeric Skin For The Treatment Of Skin Lesions In Patients With Epidermolysis Bullosa

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    cx501 ...

  • Study Participants

    12
A phase II, comparative, open label, prospective, multicentre clinical trial where each patient will undergo two procedures; implant of a patch of cultured chimeric skin (experimental therapy) in a half of the skin lesion and an occlusive non-adherent dressing (control) in the other half for 12 months of follow-up in two Spanish centres.
Reconstruction of interdigital commisures in patients with severe skin syndactyly using laminar grafts that will be uniformly and systematically taken with an electrical or compressed air dermatome on an aseptic area and with the same extent and depth in microns in all patients.

Immediately after the surgical procedure, a patch of cultured chimeric skin (experimental therapy) will be implanted in a half of the skin defect of the patient, and an occlusive non - adherent dressing (control) will be implanted in the other half.

Patients will initially be followed up every two days until epithelisation occurs (approximately 21 days after surgery) and at 3,8,and 12 months of follow-up.
Study Started
Dec 31
2006
Primary Completion
May 31
2010
Study Completion
May 31
2010
Last Update
Aug 01
2019

Drug CX501

Cultured chimeric skin

Device Occlusive non adherent dressing

Application of an occlusive non adherent dressing in the skin donor site

CX501 Experimental

Cultured chimeric skin

Non adherent dressing Active Comparator

Occlusive non adherent dressing

Criteria 

Inclusion criteria:

Patients of both sexes over 28 days of age.
Patients with recessive dystrophic epidermolysis bullosa diagnosed by clinical and historical criteria with severe skin syndactyly in whom reconstructive surgery is indicated.
Patients whose legal guardians have given written informed consent for participation in the study before any study procedure is performed.
Patients aged ≥ 12 years who have given written informed consent for participation in the study before any study procedure is performed.

Exclusion criteria:

Women of childbearing age not using effective contraceptive methods (oral contraception)
Pregnant or nursing women
Documented or suspected hypersensitivity to any of the therapeutic agents included in the study, including anaesthetic drugs.
Patients with a history of malignant tumor in the past 5 years
Patients with a diagnosis of active tuberculosis at the time of recruitment
Patients with prior positive markers for any of the following pathogens: hepatitis b and c, hiv-1 and hiv-2
Patients with a history of clinically relevant hepatic, gastrointestinal, haematological, pulmonary, or neurological disease no directly related to epidermolysis bullosa.
Any other medical condition which, in the investigator´s judgment, might interfere with optimal participation in the study or involve a significant risk for the patient.
Alcoholism, drug addiction, psychiatric disorders, or other factors present in legal guardians which,in the investigator´s judgment may complicate patient participation in the study.
No Results Posted