Trial | NCT00955643  Report issue

Title

Periodontal Treatment Associated With Hyperbaric Oxygen Therapy
Periodontal Therapy in Severe Cases of Periodontitis: Preliminary Findings of Non-surgical Instrumentation With or Without Hyperbaric Oxygen Therapy (HBOT)

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    oxygen ...

  • Study Participants

    20
Evaluation of the clinical effect of hyperbaric oxygen therapy (HBOT) adjunctively to scaling and root planing (SRP) in the treatment of severe case of chronic periodontitis.
Materials and Methods: In 20 patients diagnosed with severe generalized chronic periodontitis (pockets>7mm) with bleeding on probing, SRP was rendered in all pockets. Additionally, five consecutive hyperbaric sessions were administered in 10 patients after random allocation (SRP+HBOT). Clinical parameters were assessed at baseline up to 6 months: plaque index (PI), bleeding on probing, probing depth, clinical attachment level and BANA test.

Results: SRP+HBOT resulted in greater probing reduction and attachment gain than SRP alone 3 months after treatment (p<0.001). The BANA test was negative after 1 week only for sites in the SRP+HBOT group (p<0.05). However SRP+HBOT failed to show a significant difference from SRP group after 3 months were all BANA sites became negative (p>0.05).

Conclusion: These preliminary data suggest that hyperbaric oxygen therapy had a short-term beneficial effect on pocket reduction and bacterial elimination, and may be considered a potential therapy option to improve the clinical outcomes of scaling in severe cases of chronic periodontitis.
Study Started
Mar 31
2002
Study Completion
Apr 30
2003
Last Update
Aug 10
2009
Estimate

Other oxygen

Other other

hyperbaric therapy Experimental

Hyperbaric therapy by oxygen

dental scaling and root planing Experimental

dental scaling and cleaning

Criteria 

Inclusion criteria:

This preliminary (pilot) study was designed with twenty subjects (12 men, 8 women, mean age 37.3 years) selected from a pool of 360 patients referred to the Periodontal Clinic of the School of Dentistry at Bahian Science Foundation (FBDC, Bahia, Brazil).
The patients had an initial diagnosis of severe generalized chronic periodontitis (AAP 1999).

Exclusion criteria:

Patients were excluded according to the following criteria:

smoking
pregnancy or lactation
antibiotics or periodontal treatment within the last 6 months
a diagnosis of aggressive periodontitis
trauma from occlusion or endodontic lesions
According to an accurate clinical examination performed by a hyperbaric medical doctor (MD), the HBOT contra-indications (Iazzeti & Mantovani 1998) served as exclusion criteria.
The only absolute contraindication to hyperbaric oxygen therapy was from patients with untreated pneumothorax

Relative contraindications were considered:

upper respiratory infections
high fevers
emphysema with CO2 retention
historic of thoracic surgery
malignant disease and middle ear barotrauma

Patients taking or have recently taken the following drugs:

doxorubicin (Adriamycin®)
disulfiram (Antabuse®)
Cis-platinum and mafenide acetate (Sulfamylon®).
No Results Posted