Title
Dietetic Efficacy of Mare's Milk for Patients With Chronic Inflammatory Bowel Diseases
Dietetic Effects of Mare's Milk in Patients With Chronic Inflammatory Bowel Diseases (IBD) - a Double Blind Placebo Controlled Cross-over Study.
Phase
N/ALead Sponsor
Friedrich Schiller UniversityStudy Type
InterventionalStatus
Completed Results PostedIndication/Condition
Ulcerative Colitis Crohns DiseaseIntervention/Treatment
mare milk ...Study Participants
17Mare's milk consumption could improve the well-being in patients with Crohn's disease and ulcerative colitis, respectively.
Background: Dietetic effects of mare's milk have been reported for a long time and can be based on bactericidal and immunological components of mare's milk.
Objective: Dietetic effects of oral intake of mare's milk in adolescent patients with chronic inflammatory bowel diseases were investigated.
Design: In a randomized, placebo-controlled, double-blind, cross-over intervention study, eight Crohn's disease patients and nine ulcerative colitis patients received daily 250 mL mare's milk or placebo drink.
oral intake of 250 ml mare's milk first, then placebo drink daily during 8 weeks of each (cross over design)
oral intake of 250 ml placebo drink first, then mare's milk daily during 8 weeks of each (cross over design)
oral intake of of 250 ml placebo drink
oral intake of of 250 ml mare´s milk
Inclusion Criteria: clear and definite diagnosis of ulcerative colitis and Crohn's disease resp. Exclusion Criteria: lactose intolerance and pregnancy
| Event Type | Organ System | Event Term |
|---|
score for Crohn´s disease: Crohn´s Disease Activity Index (CDAI), < 150 = remission, 151-220 = moderate activity, 221-450 = severe activity; score for ulcerative colitis: Colitis Activity Index (CAI), 0-4 = remission, 5-9 = low activity, 10-16 = moderate activity, 17-23 = high activity.
The patients recorded daily their extraintestinal disorders (fever, anal fissures, stomatitis, arthralgia, skin irritation) using a treatment improvement protocol (TIP).
