Trial | NCT00933634  Report issue

Title

Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation
Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation: a Randomized Controlled Trial

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    propafenone ...

  • Study Participants

    247
The optimal strategy to restore sinus rhythm in patients with atrial fibrillation (AF) of less than 48 hours' duration is still controversial. The investigators performed a controlled single-center trial to compare electrical and pharmacological (propafenone) cardioversion to restore the sinus rhythm in selected patients with acute atrial fibrillation.
Study Started
Jan 31
2006
Primary Completion
Nov 30
2008
Study Completion
Nov 30
2008
Last Update
Jul 07
2009
Estimate

Procedure electrical cardioversion

External cardioversion was performed in anteroposterior position (right sternal body at the third intercostal space-angle of the left scapula); patients were submitted to a biphasic wave-form sequential shock of 100-150-200 J, if necessary.

Drug propafenone

Propafenone (2 mg/kg bolus) was administered to obtain pharmacolgic sinus rhythm conversion.

electrical cardioversion Experimental

Patients were sedated with propofol and external cardioversion was performed in anteroposterior position (right sternal body at the third intercostal space-angle of the left scapula). Patients were submitted to a biphasic wave-form sequential shock of 100-150-200 J, if necessary.

propafenone Active Comparator

Propafenone (2 mg/kg bolus) was administered iv to obtain pharmacologic sinus rhythm conversion.

Criteria 

Inclusion Criteria:

atrial fibrillation of less than 48 hours' duration.

Exclusion Criteria:

AF of more than 48 hours'
hemodynamic instability
acute onset atrial fibrillation due to acute coronary syndrome
electrolyte disturbances
sepsis
fever
hypothermia
untreated hyperthyroidism
use of antiarrhythmic drugs
high embolic risk
unclear duration of symptoms
No Results Posted