Title
Efficacy of High-oleic Canola and Flaxseed Oils for Hypercholesterolemia and Cardiovascular Disease Risk Factors
Efficacy of Consumption of High-oleic Canola and Flaxseed Oils in the Management of Hypercholesterolemia and Other Cardiovascular Risk Factors
Phase
Phase 2Lead Sponsor
University of ManitobaStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Cardiovascular DiseaseIntervention/Treatment
oleic acid ...Study Participants
36The purpose of this study is to assess the efficacy of high-oleic canola oil and a high-oleic canola/flaxseed oil blend as compared to a typical Western diet on plasma lipids, fatty acid profiles, and risk factors associated with cardiovascular disease in hypercholesterolemic patients. Furthermore, the metabolism of dietary oleic acid and alpha-linolenic acid contained in high-oleic canola oil and flaxseed oil will be investigated.
Diets contained 35% energy as fat; of which 70% was provided by high-oleic canola oil (high in monounsaturated fat (oleic acid))
Diets contained 35% energy as fat; of which 70% was provided by a 1:1 blend of high-oleic canola oil and flaxseed oil (high in monounsaturated fat (oleic acid) and omega-3 polyunsaturated fat (alpha-linolenic acid))
Diets contained 35% energy as fat; of which 70% was provided by a blend of oils typical to the Western diet (high in saturated fat and omega-6 polyunsaturated fat (linoleic acid))
Inclusion Criteria: Fasting serum LDL-Cholesterol >3.0 mmol/L Body mass index (BMI) between 22-36 kg/m2 Exclusion Criteria: smoking use of lipid lowering therapy documented cardiovascular/atherosclerotic disease inflammatory disease diabetes uncontrolled hypertension kidney disease other systemic diseases cancer chronic alcohol consumption (> 2 servings/day) excessive exercise expenditure (> 4000 kcal/week)
