Official Title
Chronic Subdural Hematoma - Reduction of Recurrence by Treatment With Angiotensin Converting Enzyme Inhibitors
Phase
N/ALead Sponsor
University of Southern DenmarkStudy Type
InterventionalStatus
Terminated Results PostedIndication/Condition
Hematoma, Subdural, ChronicIntervention/Treatment
perindopril ...Study Participants
47The project aims at investigating if treatment with the Angiotensin Converting Enzyme inhibitor Coversyl (perindopril) for 3 months after surgery for chronic subdural hematoma will decrease the risc of recurrence.
Previous studies have indicated that treatment with ACE inhibitors can reduce the risk of recurrence of CSDH after surgical evacuation. This randomized clinical trial was designed to investigate this
2,5 mg daily for 3 months
Placebo dayli for 3 months
patients randomized to this arm will be treated with ACE inhibitors after surgery
patients randomized to this arm will be treated with placebo after surgery
Inclusion Criteria: Patients with chronic subdural hematoma that needs surgical evacuation Age > 18 year Exclusion Criteria: Lack of compliance Kidney artery stenosis Stenosis of the aorta Severely decreased kidney function Allergy or intolerance/contraindications toward ACE inhibitors Already in ACE inhibitor treatment Coagulopathies Malignant disorders Fertile women Other neurological disorders Treatment with pharmaceuticals contraindicating treatment with ACE inhibitors
| Event Type | Organ System | Event Term |
|---|
Volume of CSDH remnant three months after evacuation measure using xyz/2 on CT scans
Post-Hoc Outcome Measure
