Trial | NCT00909558  Report issue

Title

Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on Cancer
A Phase I Open Label, Single Site, Safety and Efficacy Study of the Effects of Autologous Natural Killer and Natural Killer T Cell Immunotherapy on Malignant Disease

  • Phase

    Phase 1

  • Study Type

    Interventional

  • Status

    Suspended

  • Study Participants

    24
The purpose of this study is to assess the safety and effectiveness of natural killer (NK) cell and natural killer T (NKT) cell-based autologous adoptive immunotherapy in subjects with metastatic, treatment-refractory breast cancer, glioma, hepatocellular carcinoma, squamous cell lung cancer, pancreatic cancer, colon cancer or prostate cancer.
Study Started
May 31
2009
Primary Completion
Jun 30
2010
Anticipated
Last Update
Feb 24
2010
Estimate

Biological Autologous Natural Killer / Natural Killer T Cell Immunotherapy

The study drug is derived from ex vivo expansion of each subject's own white blood cells and is therefore autologous. The current study proposes a 3-course treatment of doses administered at one week intervals with monitoring at each administration plus 2 weeks after the last dose. The total study time (apheresis through last follow-up) is estimated at 15 weeks.

Criteria 

Inclusion Criteria:

Male or female not less than 18 years of age or over 80 years of age.
Life expectancy of ≥ 24 weeks as measured by the Eastern Cooperative Oncology Group (ECOG) performance status.
Subjects must present with one of the following disease pathologies: Breast Cancer, Glioma, Hepatocellular Cancer, Squamous Cell Lung Cancer, Pancreatic Cancer, Colon Cancer or Prostate Cancer
The pathology must be an assessable disease (measurable by CT scan or MRI) that is refractory to standard treatments (e.g., chemotherapy, radiation, etc.)
Negative for hepatitis B, hepatitis C, HIV, and CMV.
Subjects must present with leukocyte counts above 3,000/μL and platelet counts above 100,000/ μL.
Subjects must present with minimum hemoglobin levels of 10.
If female, subject is surgically sterile (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy), post menopausal (no menses >12 months), or using a high-efficiency method of contraception such as implant, injectable, combination oral contraceptive, intrauterine device (IUD) or sexual abstinence, or has a vasectomized partner.
If female of childbearing potential, subject is not pregnant, breast-feeding or planning a pregnancy during the study, and has a negative pregnancy test on screening visit.
Able to comprehend and sign an informed consent document and comply with the requirements of the study.

Exclusion Criteria:

No measurable malignant disease by CT scan or tumor markers.
Life expectancy of ≤ 24 weeks as measured by the Eastern Cooperative Oncology Group (ECOG) performance status.
Age of less than 18 years or over 80 years of age.
Documented/confirmed positive testing for hepatitis B, hepatitis C, HIV, or CMV.
Prior or current history of autoimmune disease.
Pregnant or lactating women.
Leukocyte count < 3,000 /μL prior to leukapheresis.
Platelet count < 100,000/μL prior to leukapheresis.
Hemoglobin levels below 10.
PTT (prothrombin time) of < 12 seconds or > than 15 seconds.
aPTT (activated partial thromboplastin time) of < 25 seconds or > than 39 seconds.
Failure or refusal to sign informed consent for the study.
Culture fails to meet specifications for study.
Subject has any other medical condition that, in the opinion of the investigator, might significantly affect the ability to safely participate in the study or affect the conduct of the study.
No Results Posted