Trial | NCT00892229  Report issue

Title

Buccal Versus Vaginal Misoprostol in Surgical Termination of the First Trimester Missed Abortion in Erbil
Buccal Versus Vaginal Misoprostol for Cervical Ripening Prior to Surgical Termination of the First Trimester Missed Abortion in Erbil

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    misoprostol ...

  • Study Participants

    100
The purpose of this study is to determine the effectiveness of buccal misoprostol and comparing this with vaginal route of the same drug.
Study Started
Mar 31
2007
Primary Completion
Jan 31
2008
Study Completion
Mar 31
2008
Last Update
May 04
2009
Estimate

Drug Misoprostol (given buccally)

400 microgram misoprostol given buccally three hours before dilation and curettage (PHARMACIA CORPORATION - Istanbul, serial number 022-00, a tablet contains 200 micrograms)

  • Other names: serial number 022-00

Drug Misoprostol (given vaginally)

400 microgram misoprostol (MISOPROSTOL - PHARMACIA CORPORATION - Istanbul, serial number 022-00, a tablet contains 200 micrograms)

  • Other names: serial number 022-00

Buccal Misoprostol Active Comparator

Group one: 50 patients with first trimester missed abortion received buccal misoprostol

Vaginal Misoprostol Active Comparator

Group two: 5 patients received vaginal misoprostol

Buccal and Vaginal Misoprostol Active Comparator

50 primiparous and 50 multiparous women: one hundred patients have been administered the medication buccally (25 primigravida and 25 multigravida), and vaginally (25 primigravida and 25 multigravida), three hours before dilation and curettage. They were admitted to the hospital one day before the surgical evacuation, and preparation of cross matched blood done for all recruited subjects. Each group was randomly allocated (1,3,5,... for the buccal group & 2,4,6,... for the vaginal group) to receive 400 microgram misoprostol.

Criteria 

Inclusion Criteria:

first trimester missed abortion

Exclusion Criteria:

history or evidence of disorders that represent contraindication to the use of misoprostol:

severe pulmonary diseases
congenital or acquired heart diseases
glaucoma
prolonged use of corticosteroid
sickle cell anemia and adrenal insufficiency
smokers
known hypersensitivity to drugs
any evidence of infection
patient's refusal to participate in the study
patients with abnormal results of investigations
patients with previous operations on cervix like conisation, cauterization, previous dilatation and curettage
patients with complete abortion
patients with severe bleeding that required emergency surgical evacuation of the uterus
patients with partially dissolved tablets at the site of application in both groups
No Results Posted