Trial | NCT00825071  Report issue

Title

Dexamethasone for Postoperative Nausea and Vomiting
Optimizing Anesthesia Antiemetic Measures Versus Combination With Dexamethasone or Ondansetron in the Prevention of Postoperative Nausea and Vomiting.

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    180
The investigators want to test the efficacy of these anesthetic antiemetic measures collectively with or without ondansetron or dexamethasone, in the prevention of postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy.
More than half of the patients undergoing laparoscopic cholecystectomy will have postoperative nausea and vomiting (PONV). PONV is related to surgical, anesthetic and patient factors.

We want to test the efficacy of these anesthetic antiemetic measures collectively with or without ondansetron or dexamethasone, in the prevention of PONV in patients undergoing laparoscopic cholecystectomy.

Three groups to be studied : (Group O) will receive 4 mg ondansetron, (Group D) will receive 8 mg dexamethasone and (Group P) will receive normal saline .
Study Started
Nov 30
2007
Primary Completion
Mar 31
2008
Study Completion
Mar 31
2008
Last Update
May 13
2016
Estimate

Drug Dexamethasone

8 mg, Intravenous

Drug Ondansetron

4 mg, intravenously

Drug normal saline

2 ml, intravenously

Group D Active Comparator

Dexamethasone group : This group received 8 mg dexamethasone

Group O Active Comparator

Ondansetron Group: received 4 mg ondansetron

Group P Placebo Comparator

(Group P) received normal saline (Placebo)

Criteria 

Inclusion Criteria:

(ASA) grade I and II, aged (18-70 years) who are scheduled for elective laparoscopic cholecystectomy under general anesthesia at the department of Anesthesia and Intensive Care, University of Jordan, Amman, Jordan between November 2007 and March 2008

Exclusion Criteria:

All patients who received antiemetics or cortisone within 48 hr before surgery or those who required opioids before and after surgeries
Pregnant, breast feeding ladies
Any patient with BMI (Body Mass Index) > 34 kg/m²
Patient with gastrointestinal, hepatic, renal, mental or psychiatric illnesses or those with history of motion sickness were also excluded from the study protocol
No Results Posted