Trial | NCT00806104  Report issue

Title

Fructo-oligosaccharides and Irritable Bowel Syndrome
Effect of Dietary Supplementation With Fructo-oligosaccharides on Visceral Sensitivity and on Taxonomic and Functional Composition of Intestinal Microbiota of IBS Patients

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    60
Fructo-oligosaccharides are known as prebiotic ingredients to modulate the composition of the intestinal microbiota and particularly to stimulate the growth of Bifidobacteria. Imbalance of the intestinal microbiota such as reduction of Bifidobacteria is implicated in Irritable Bowel Syndrome (IBS). Thus the objective of the study is to evaluate the effect of fructo-oligosaccharides to improve IBS score and to explore which modifications of the microbiota are responsible of this improvement.
Study Started
Mar 31
2009
Primary Completion
Jul 31
2010
Study Completion
Dec 31
2010
Last Update
Jan 17
2011
Estimate

Dietary Supplement Fructo-oligosaccharides

Dietary supplementation for 4 weeks

Dietary Supplement Maltodextrins

Dietary supplementation for 4 weeks

1 Experimental

Fructo-oligosaccharides

2 Placebo Comparator

Maltodextrins

Criteria 

Inclusion Criteria:

IBS subjects according to Rome III criteria
Incomfort below or equivalent to 30mmHg during Tensostat test
between 18 and 60 years
no antibiotic treatment for the last 2 months
less than 20g of dietary fibres consummed per day
no analgesic treatment
no treatment for intestinal transit

Exclusion Criteria:

subjects suffering from diabetes, colic cancer, inflammatory bowel disease, dysthyroidy, Hirschprung disease, anorexia
excessive consumption of alcohol or tobacco
participating to another clinical study
pregnant women
antidepressor or anxiolytic treatment
No Results Posted