Trial | NCT00798278  Report issue

Title

Urokinase Versus Video-assisted Thoracoscopic to Treat Complicated Parapneumonic Empyema in Childhood
Exploratory Multicentre Clinical Trial to Compare the Efficacy of Urokinase Versus Video-assisted Thoracoscopic for Treatment of Complicated Parapneumonic Empyema in Childhood

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    urokinase ...

  • Study Participants

    200
A great controversy exists about which is the best method to perform the evacuation of the collection. The purpose of this study is to evaluate which is the best initial treatment to drain complicated parapneumonic empyema (stages II and III) in children: the present study raises a hypothesis of equivalence between both arms of treatment (chest drainage plus intrapleural urokinase or videothoracoscopic debridement).
Study Started
Jul 31
2008
Primary Completion
Sep 30
2010
Study Completion
Sep 30
2010
Last Update
Oct 28
2010
Estimate

Drug Urokinase

Chest tube with intrapleural urokinase infusion for 3 days

Procedure Video-Assisted Thoracoscopic

Video-Assisted Thoracoscopic decortication

Urokinase Experimental

urokinase infusion for 3 days

Thoracoscopic Active Comparator

Video-Assisted Thoracoscopic

Criteria 

Inclusion Criteria:

Patients less than 15 years of age with pneumonia and persistent fever, and complicated parapneumonic empyema (septation or loculation seen on ultrasound or Rx thorax)stages II and III requiring an intervention to drain

Exclusion Criteria:

Existing contraindications or other previous conditions, hypertension, pneumothorax
No Results Posted