Trial | NCT00797693  Report issue

Title

Misoprostol in Termination of First Trimester Missed Abortion
Oral Versus Vaginal Misoprostol as Cervical Ripening Agent Prior to Surgical Termination of First Trimester Missed Abortions in Hawler Maternity Teaching Hospital in Erbil/Iraq

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    misoprostol ...

  • Study Participants

    100
The purpose of this study is to determine whether oral versus vaginal misoprostol is effective in termination of first trimester missed abortion and to compare between two different routes.
Objective: To compare the effectiveness of oral versus vaginal misoprostol prior to surgical termination of first trimester missed abortion as cervical priming agent , the difference of cervical dilatation immediately prior to operation , the duration of operation and side effects between two treatment groups.

Design: This study was conducted as randomised study.

Setting: Maternity Teaching Hospital in Hawler/ Kurdistan/ Iraq.

Population: Over a period of six months from the first of January to the thirtieth of June, 2008, one hundred women were included in this study. They were cases of first trimester abortion (6-12 weeks).

Method: Patients were randomly selected for the type of treatment they received. The first group (oral) were assigned to receive 400 micrograms of misoprostol orally as preoperative cervical priming agent, where as the second group (vaginal) were allocated to have treatment either with vaginal misoprostol to receive 400 micrograms vaginally.

Main outcome measure: Oral versus vaginal misoprostol as cervical ripening agent prior to termination of first trimester missed abortion.

Keywords: First trimester, missed abortion, misoprostol, cervical ripening, oral, vaginal.
Study Started
Jan 31
2008
Primary Completion
May 31
2008
Study Completion
May 31
2008
Last Update
Nov 25
2008
Estimate

Drug Misoprostol ( Cytotec) 200 microgram a tablet

In this study, two arms we put under study ... and to find how far a single drug, Misoprostol, is effective to have changes on the cervix.

  • Other names: PHARMACIA CORPORATION - Istanbul, serial number 022-00, 200 microgram a tablet

Vaginal Misoprostol Experimental

A drug is given vaginally and to compare this with an oral administration of the same drug to find it is effect on it is effect on the cervix

Oral Misoprostol Experimental

A drug is given vaginally and to compare this with an oral administration of the same drug to find it is effect on it is effect on the cervix

Criteria 

Inclusion Criteria:

All patients were cases of first trimester missed abortion.
They have uneventful history apart from history of slight vaginal bleeding, with normal general examination. Gynecological examination revealed no vaginal bleeding or discharge with no dilatation of the internal os with enlarged uterus.

Exclusion Criteria:

Cases with suspected or proven ectopic pregnancy, history of Caesarean section, medical diseases, a known hypersensitivity to a drug, smokers, patients with abnormal results of investigation and the presence of vaginal bleeding were excluded from the study.
No Results Posted