Trial | NCT00791505  Report issue

Title

Antibiotic/COPD in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Requiring Mechanical Ventilation
Antibiotic Comparison Exacerbation COPD

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    170
Although the use of antibiotics in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) is largely accepted, controversy remains regarding whether the choice of antibiotic has any impact on outcome. Our aim was to compare the effects of the combination of trimethoprim and sulfamethoxazole and ciprofloxacin in patients treated for severe COPD exacerbation requiring mechanical ventilation.
Antibiotic therapy has been shown to be beneficial in patients with severe acute exacerbation of chronic obstructive pulmonary disease (COPD). Although recent guidelines support the use of new antibiotics there is no evidence that newer antibiotics are any better than older agents. The choice of antibiotic to be used in this situation is challenging to the clinician who must choose between traditional antibiotics (cyclins, aminopénicillins, cotrimoxazole...) and new antimicrobial agents. Indeed, available comparative studies did not show an obvious superiority of new antibiotics compared to their predecessors . Taking into account bacterial agents associated to COPD exacerbations, one must choose an antibiotic which has the best activity against Haemophilus influenzae, Streptococcus pneumoniae and Branhamella catarrhalis. News quinolones are represented as an interesting alternative to standard antibiotics because of their large spectrum of action and of their pharmacokinetic advantages allowing high tissue penetration in the pulmonary parenchyma and tracheobronchial tree. Data on their use among patients having moderate exacerbation of COPD are encouraging but their effectiveness in more severe presentations is not established. The objective of this randomized controlled and double blind study is to evaluate the effectiveness and tolerance of ciprofloxacin compared to trimethoprim sulfamethoxazole in patients admitted to ICU for severe exacerbation of COPD requiring mechanical ventilation.
Study Started
Jul 31
2002
Primary Completion
Jun 30
2005
Study Completion
Jun 30
2005
Last Update
Feb 24
2020

Drug ciprofloxacin

1500 mg a day for 10 days

  • Other names: fluoroquinolone

Drug trimethoprim-sulfamethoxazole

2000 mg a day for 10 days

  • Other names: sulfatrim, bactrim

Ciprofloxacin Active Comparator

750 mg a day during 10 days

trimethoprim-sulfamethoxazole Active Comparator

2000 mg a day for 10 days

Criteria 

Inclusion Criteria:

All patients having a COPD (according to the definition of the American Thoracic Society) and having an acute exacerbation leading to an acute respiratory failure requiring the admission to ICU and mechanical ventilation.
The acute exacerbation of COPD is defined by increase in the frequency of cough, the volume and the purulence of expectoration and increase of baseline dyspnea. To be included, patients must have respiratory rate >30 cycles/min and one of the following blood gas criteria (with blood gases performed right before the initiation of mechanical ventilation): PaC02 > 6kPa and arterial pH <7.30.

Exclusion Criteria:

Pneumonia documented with chest radiography
Antibiotic treatment in the ten previous days of ICU admission
Former inclusion in the study
History of allergy to the quinolones and/or to trimethoprim sulfamethoxazole
Pregnancy or breast feeding
Severe chronic disease: heart, liver, kidney.
Known immunodeficiency (malignant hemopathy, AIDS...)
Digestive disease which could affect the absorption of the drugs
Concomitant infection which requires systemic antibiotic treatment
No Results Posted