Trial | NCT00784472  Report issue

Title

Visceral Pain From the Upper Urinary Tract - a Trial on the Effect of Morphine and Oxycodone in Patients Undergoing PCNL
Visceral Pain Originating From the Upper Urinary Tract - a Randomized Controlled Trial on the Effect of Morphine and Oxycodone in Patients Undergoing Percutaneous Nephrolithotomy (PCNL)

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    55
The purpose of this study is to investigate the effect of oxynorm versus morphine after operation for kidney stone (PCNL). In addition the relationship between pain symptoms and referred sensory and trophic changes will be examined in the patients before and after the operation.Finally a blood sample is analysed to investigate pharmaca-genetics.
Primary outcome: the amount of opioid (morphine or oxynorm) used the first 4 hours postoperatively.

Secondary outcome: side effect to the opioids, pain score, pain threshold to electrical stimulation and pressure before and after operation, pharmacogenetics, size of referred pain area.
Study Started
Dec 31
2008
Primary Completion
Jun 30
2012
Study Completion
Jun 30
2012
Last Update
Jul 09
2012
Estimate

Drug oxycodone

intravenous according to patients weight, pn.

  • Other names: oxynorm N02A A05

Drug morphine

intravenous administration according to patients weight, pn.

  • Other names: morphine SAD N02 AA 01

oxycodone Active Comparator

morphine Active Comparator

Criteria 

Inclusion Criteria:

Age > 18
Indication for PCNL

Exclusion Criteria:

Malignant disease in the upper urinary tract
Allergy to morphine or oxycodone
Use of opioids the last 48 hours before PCNL
Pregnancy
Nursing mothers
Present JJ-stent in the ureter
Previous urinary stone disease on the opposite site
No Results Posted