Trial | NCT00757185  Report issue

Official Title

Compromised Microcirculation in Women With Polycystic Ovary Syndrome

  • Phase

    Early Phase 1

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    28
The scientific aims of the study are to determine how peripheral microcirculatory responsiveness is altered in obese women with Polycystic Ovary Syndrome (PCOS) during local heating and to determine the mechanism for testosterone effects on peripheral microcirculatory responsiveness in women with PCOS.
In these studies, we propose to use the skin as a relatively non-invasive model to examine cardiovascular and endothelial function in obese women with and without PCOS. Data have indicated an important role for testosterone in influencing the peripheral microcirculation. While testosterone can lead to vasodilation in the peripheral microcirculation in both men and in women without PCOS, testosterone appears to induce vasoconstriction in women with PCOS. The differential response between women with and without PCOS, and between men and women may be the result of differential ET-1 actions in the vessel, and regulated by the receptor subtype is involved in these actions.
Study Started
Feb 29
2008
Primary Completion
Apr 30
2012
Study Completion
Dec 31
2012
Last Update
Jul 04
2016
Estimate

Drug ganirelix acetate

GnRH antagonist, subcutaneous injection, 0.25 mg/day for 21 days

  • Other names: Antagon

Drug methyl testosterone

testosterone, oral administration, day 5 of GnRH administration, 2.5 mg/day

1 Experimental

GNRH antagonist alone

2 Experimental

GnRH with Testosterone

Criteria 

Inclusion Criteria:

Obese women (18-35) years with and without PCOS

Exclusion Criteria:

Conditions that would preclude safe use of hormones
No Results Posted