Trial | NCT00738348  Report issue

Official Title

Effect of Perioperative Sivelstat Administration for Liver Resection

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    50
It is reported that sivelstat improved and preserved the postoperative renal function in the orthopedic management. Moreover because sivelstat reduced the migration of neutrophil, it improved acute lung injury. During liver resection, Pringle maneuver, clamping the hepatoduodenal ligament, was performed. Pringle maneuver causes reperfusion injury of the liver. We have a hypothesis that sivelstat prevent the warm shock of reperfusion injury of the liver by Pringle maneuver.
Whether the incidence of postoperative morbidities, such as liver failure, renal failure, or congestive heart failure, was reduced by administration of perioperative sivelstat.
Study Started
Apr 30
2007
Primary Completion
May 31
2008
Study Completion
Jul 31
2008
Last Update
Jun 08
2012
Estimate

Drug sivelstat

sivelstat sodiumhydrate

  • Other names: sivelstat sodiumhydrate, ONO PHARMACEUTICAL CO

Drug glucose

glucose

2 Active Comparator

250mL of 5% glucose plus 300mg of sivelstat was infected through the vein at 10mL per an hour

1 Placebo Comparator

250mL of 5% glucose was injected though the vein at 10mL per an hour

Criteria 

Inclusion Criteria:

liver disease which surgical management was indicated

Exclusion Criteria:

weight loss greater than 10 per cent during the previous 6 months, signs of distant metastasis, or of respiratory, renal or heart disease
No Results Posted