Trial | NCT00719056  Report issue

Title

Teicoplanin Prophylaxis for Total Hip or Knee Arthroplasty
Efficacy of Teicoplanin for the Prevention of Surgical Site Infections After Total Hip or Knee Arthroplasty: A Prospective, Open-Label Randomized Study

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    teicoplanin ...

  • Study Participants

    616
This is a prospective, open-label, randomized clinical trial where patients were administered prophylaxis for total hip or knee arthroplasty either with teicoplanin or with other antibiotics. The study is aiming to evaluate any differences between these two different strategies of antimicrobial prophylaxis in the occurrence of surgical site infections
This is a prospective, open-label, randomized clinical trial where patients were administered prophylaxis for total hip or knee arthroplasty either with a single dose of teicoplanin or with multiple doses of other antibiotics according to the habits of the attending physicians aiming to evaluate any differences between these two different strategies of antimicrobial prophylaxis in the occurrence of surgical site infections
Study Started
Aug 31
2004
Primary Completion
Dec 31
2005
Study Completion
Dec 31
2007
Last Update
Jul 21
2008
Estimate

Drug Teicoplanin

The selected dose was 10mg/kg and it was given intravenously by a catheter inserted under aseptic conditions in a forearm vein within 15 minutes; it was diluted in one 5% glucose solution of a 50 ml final volume

  • Other names: Glycopeptide

Drug β-lactams or ciprofloxacin

Multiple doses for up to six consecutive days

  • Other names: Cephalosporins or ciprofloxacin or penicillincs

1 Experimental

Surgical chemoprophylaxis of one dose of teicoplanin upon introduction of anesthesia for total hip or knee arthroplasty.

2 Active Comparator

Surgical chemoprophylaxis with multiple dose of other antimicrobials for up to six consecutive days for total hip or knee arthroplasty.

Criteria 

Inclusion Criteria:

Patients admitted for total hip arthroplasty
Patients admitted for total knee arthroplasty

Exclusion Criteria:

Revision arthroplasty
History of any infection within the preceding two months
History of an operation in the same hip or knee for other causes
Known history of allergy to the studied drug
Pregnancy or lactation
Any antibiotic therapy in the week before operation.
No Results Posted