Trial | NCT00707824  Report issue

Title

Epidural Nalbuphine for Postcesarean Epidural Morphine Induced Pruritus
Study of Epidural Nalbuphine for Prevention of Epidural Morphine Induced Pruritus

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    165
Can epidural nalbuphine reduce incidence or severity of epidural morphine induced pruritus in patient undergoing cesarean section?
182 parturients,ASA 1-2 undergoing cesarean section under epidural block were enrolled in the study. After obtaining informed consent,all received epidural anesthesia using 2% lidocaine with epinephrine 1:200000 via epidural cathetes at L2-3 or L3-4 in a volume suffient to achieve a T4 sensory level bilaterally.

After the umbilical cord was clamped,patients were assigned randomly to three groups.The placebo group,N-5 group,and N-10 group received 4 ml epidural solution containing morphine 4 mg plus either saline, nalbuphine 5 mg, and nalbuphine 10 mg respectively.At the post anesthetic care unit, intravenous pethidine PCA were administered for inadequate pain control.

Outcome measures :

Incidence and severity of postoperative pruritus Quality of pain control Side effects of epidural morphine and nalbuphine such as respiratory depression,sedation
Study Started
Jun 30
2000
Primary Completion
Dec 31
2005
Study Completion
Feb 28
2006
Last Update
Jul 08
2008
Estimate

Drug nalbuphine

nalbuphine 5 mg epidural

  • Other names: nubain

Drug nalbuphine

nalbuphine 10 mg epidural

  • Other names: nubaine

Other NSS

NSS

  • Other names: nornal saline

1 Placebo Comparator

1= placebo

2 Active Comparator

2=nalbuphine 5 mg

3 Active Comparator

3=nalbuphine 10 mg

Criteria 

Inclusion Criteria:

full term parturient undergoing elective cesarean section
ASA 1-2

Exclusion Criteria:

drug or alcohol abuses
contraindication for regional anesthesia
received opioids within 12 hours
No Results Posted