Trial | NCT00699946  Report issue

Title

Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery
A Double-Blind, Randomized, Placebo-Controlled Study of Perioperative Administration of Olanzapine to Prevent Postoperative Delirium in Joint Replacement Patients

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    olanzapine ...

  • Study Participants

    495
In this study we wanted to determine if perioperative administration of olanzapine prior to knee or hip replacement surgery in high risk patients would prevent the onset of postoperative delirium.
Postoperative delirium is a serious and common (20% to 60%) complication in orthopedic surgery patients. In this study we investigate whether prophylactic administration of olanzapine can prevent delirium from occurring after knee or hip replacement in high-risk patients > 65 years of age. This is a randomized, double-blind, single center, placebo-controlled study.
Study Started
Jan 31
2005
Primary Completion
Aug 31
2007
Study Completion
Oct 31
2007
Last Update
Jan 21
2009
Estimate

Drug olanzapine

5 mg preoperative and 5mg postoperative prior to discharge to inpatient nursing floor

  • Other names: Zyprexa

Drug placebo

placebo administered preoperatively and postoperatively prior to discharge to inpatient nursing floor

1 Active Comparator

2 Placebo Comparator

Criteria 

Inclusion Criteria:

High risk for delirium age > 65 history of delirium medical comorbidities ability to give informed consent

Exclusion Criteria:

Dementia Alcohol abuse Current use of an antipsychotic Allergy to olanzapine
No Results Posted