Trial | NCT00693680  Report issue

Title

Zinc Supplementation of Imipramine Therapy
The Role of Zinc in Therapy of Unipolar Depression

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    zinc ...

  • Study Participants

    60
Examination of the effect of zinc supplementation on imipramine therapy in major depression.
A placebo-controlled, double blind study of zinc supplementation in imipramine therapy was conducted in sixty, depressed patients fulfilling the DSM-IV criteria for major depression without psychotic symptoms. After a one week washout period, patients were randomized into two groups treated with imipramine and receiving once daily either placebo (n=30) or zinc supplementation (n=30) for 12 weeks.
Study Started
Jan 31
2005
Primary Completion
Apr 30
2006
Study Completion
Apr 30
2006
Last Update
Jun 13
2008
Estimate

Dietary Supplement Zincas Forte

25 mgZn/day + imipramine (100-200mg/day)

  • Other names: Zincas Forte (Farmapol, Poland), Imipramin (Polfarma, Poland)

Dietary Supplement Placebo

placebo + imipramine (100-200mg/day)

  • Other names: Imipramin (Polfarma, Poland)

1 Active Comparator

zinc + imipramine

2 Placebo Comparator

placebo + imipramine

Criteria 

Inclusion Criteria:

patients with fulfilled DSM-IV criteria for moderate or severe depressive episode
one week washout period without any pharmacotherapy

Exclusion Criteria:

psychotic symptoms
No Results Posted