Trial | NCT00680680  Report issue

Title

Treatment of Refractory Urinary Retention Secondary to Benign Prostatic Hyperplasia (BPH) With Dual Five Alpha Reductase Inhibition Combined With an Alpha Blocker
Phase 4 Study of Dual Five Alpha Reductase Inhibition Combined With Alpha Blockade in Men With Refractory Urinary Retention Secondary to BPH

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    20
To determine whether the addition of a dual Five Alpha Reductase Inhitor (Dutasteride) will alleviate urinary retention secondary to BPH in who have failed a voiding trial without a catheter. Following treatment with an Alpha Blocker alone.
Study Started
May 31
2004
Primary Completion
Feb 29
2008
Study Completion
Feb 29
2008
Last Update
May 20
2008
Estimate

Drug Dutasteride

Patients will continue on their alpha blocker in addition to Dutasteride 0.5mg daily for a maximum of 3 months

Criteria 

Inclusion Criteria:

Males betewen the ages of 50 and 90 years of age.Written informed consent.
Men with acute urinary retention attributed to bladder outlet obstruction caused by BPH, who have failed atleast 1 week trial of alpha blocker treatment.
PSA level equal to or greater than 1.5ng/ml and equal to or less than 15 ng/ml.

Exclusion Criteria:

Urinary retention attributed to a neurogenic or myogenic bladder dysfunction.
Use of psychotrophic medications.
Use of antichollinergic medications.
Prostate cancer.
Allery to five alpha reductase inhibitors.
Prior prostate surgery.
Urethral stricture.
Bladder calculi.
Invasive bladder cancer.
Inability to understand or agree with the requirements of the study.
Any investigational drug received within 30 days prior of study entry.
No Results Posted