Trial | NCT00676377  Report issue

Title

A New Approach of Neostigmine in Unavoidable Post Operative Ileus
A New Approach of Neostigmine in Unavoidable Post Operative Ileus After Surgery

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Indication/Condition

    Ileus

  • Study Participants

    3
Postoperative ileus (POI) in the absence of any mechanical obstruction remains a commonly encountered clinical problem.So, this study aimed to show the effective way to decrease the rate of postoperative Ileus (POI).
We honestly declare that, the use of parasympathomimetic agents such as neostigmine is not without risk. Patients with underlying bradyarrhythmias or those receiving β-adrenergic antagonists may be more susceptible to neostigmine-induced bradycardia. Similarly, neostigmine increases airway secretions and bronchial reactivity, which may exacerbate active bronchospasm. Recently, a new class of drugs-peripherally acting mu-opioid receptor antagonists-may help enhance multimodal management of POI. Although, the cost benefit of the new class of drugs is debated. It has been suggested that the individual components of multimodal protocols-for example, laparoscopy-may reduce certain post surgical morbidities (including POI) But do not by them prevent POI. Therefore, combinations of strategies with demonstrated effectiveness-early feeding , epidural analgesia, laparoscopic surgery, and use of peripherally acting mu-opioid-receptor antagonists-may help transform the reactive approach to POI into a proactive multimodal paradigm that effectively targets the diverse etiologic factors leading to this common clinical problem.
Study Started
Aug 31
2007
Primary Completion
Dec 31
2007
Study Completion
Feb 29
2008
Last Update
May 13
2008
Estimate

Drug Neostigmine

2.5 mg of neostigmine intravenously in 250 ml normal saline over a period of thirty minutes ,Half Life 3 Hours

  • Other names: Neostigmine Group

Drug Saline

Saline Placebo

  • Other names: Placebo Group

1 Experimental

Neostigmine

2 Placebo Comparator

Placebo

Criteria 

Inclusion Criteria:

Patients with acute colonic pseudo-obstruction who were 18 years of age or older
Patients had to have a cecal diameter of at least 10 cm on plain radiographs
Mechanical obstruction was ruled out by the finding of air throughout all colonic segments including the rectosigmoid on plain abdominal radiographs

Exclusion Criteria:

Exclusion criteria included a base-line heart rate of less than 60 beats per minute or systolic blood pressure of less than 90 mm Hg; signs of bowel perforation
With peritoneal signs on physical examination or free air on radiographs; active bronchospasm requiring medication
Treatment with prokinetic drugs such as cisapride or metoclopramide in the 24 hours before evaluation
A history of colon cancer or partial colonic resection
Active gastrointestinal bleeding
Pregnancy
Positive history of Myocardial Infarction, Intestinal Resection or a serum creatinine concentration of more than 3 mg per deciliter (265 µmol per liter)
No Results Posted