Trial | NCT00667758  Report issue

Title

Gonadotropin-Releasing Hormone (GnRH)-Antagonist Therapy in Rheumatoid Arthritis
Antagonist to Gonadotropin-Releasing Hormone in Rheumatoid Arthritis (AGRA): A Double-blind, Randomized, Placebo Controlled Trial

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    cetrorelix ...

  • Study Participants

    104
The purpose of this study is to compare the safety and efficacy of gonadotropin-releasing hormone (GnRH) antagonist therapy versus placebo in patients with moderate to severe rheumatoid arthritis.
Study Started
May 31
2008
Primary Completion
Jun 30
2011
Study Completion
Oct 31
2011
Last Update
Aug 06
2012
Estimate

Drug Placebo

3-5 ml NaCl s.c. on days 1-5

Drug Cetrorelix

3-5 mg s.c. on days 1-5

1 Experimental

Cetrorelix

2 Placebo Comparator

NaCl solution

Criteria 

Inclusion Criteria:

Adult between 18 years and above
Moderate to severe disease activity
Negative pregnancy test for women of childbearing potential
Use of reliable method of contraception (non-hormonal) by sexually active female patients

Exclusion Criteria:

Patients who are pregnant or breastfeeding
Patients taking biologic therapy or prednisolone >7.5mg
No Results Posted