Trial | NCT00667654  Report issue

Title

Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA)
A Phase 2, Open-label Study to Evaluate Safety and Tolerability, and to Explore the Efficacy, of Dosing Regimens of Intraarticular 4975 in Patients With Chronic Moderate to Severe Pain of the Knee Associated With Osteoarthritis

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    capsaicin ...

  • Study Participants

    54
This study will evaluate dosing regimens of 4975 in terms of safety and tolerability when delivered as an intra-articular injection in the knee. Secondary objectives will be to explore the efficacy of 4975 in terms of onset, extent and duration of pain relief.
This is a single site study. The study drug, 4975, will be administered in various dosing regimens by intra-articular injection followed by an observation period of up to 12 weeks. Pain in the treated knee will be assessed before, during and after administration of the study drug.
Study Started
Aug 31
2007
Primary Completion
Jun 30
2008
Study Completion
Aug 31
2016
Last Update
Dec 06
2016
Estimate

Drug CNTX-4975

Testing a range of dosing configurations to optimize patient tolerability

100-200 µg CNTX-4975 Experimental

single dose

300-425 µg CNTX-4975 Experimental

Total dose delivered as two separate lower doses

600-700 µg CNTX-4975 Experimental

Total dose delivered as two separate lower doses

800 µg CNTX-4975 Experimental

Total dose delivered as two separate lower doses

900-1000 µg CNTX-4975 Experimental

Total dose delivered as two separate lower doses

Criteria 

Inclusion Criteria:

Male or female patients aged 40 years or over.
Body mass index (BMI) of 35 or less.
History of OA of the knee for at least 1 year and has experienced pain in the target area for at least six months.
X-Ray of the target knee.
Willing and able to complete the study procedures.

Exclusion Criteria:

Female patients who are pregnant or lactating or who plan to get pregnant.
Clinically significant form of joint disease other than OA.
Medical condition that could adversely impact the patient's participation, safety or affect the conduct of the study.
Prior major trauma in the target knee or major surgeries such as partial or total knee arthroplasty.
Arthroscopic surgery on the target knee within 6 months.
No Results Posted