Trial | NCT00665119  Report issue

Title

Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients
Effects of Remifentanil on Breathing Pattern, Respiratory Effort and Gas Exchange in Mechanically Ventilated Patients.

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    remifentanil ...

  • Study Participants

    14
Sedation is widely used in mechanically ventilated patients. Propofol, benzodiazepines and opioids are the most used drugs. The study hypothesis is that sedation with remifentanil (an opioid drug) could improved respiratory pattern and effort in mechanically ventilated patients with rapid shallow breathing or high respiratory rate.
Study Started
Apr 30
2008
Primary Completion
Oct 31
2008
Study Completion
Oct 31
2008
Last Update
Dec 18
2008
Estimate

Drug remifentanil

0.05 mcg.kg-1.min-1 for 30 minutes by continuous endovenous infusion

Drug placebo

NaCl 0.9 %

treatment Experimental

Any patient alternatively receive both remifentanil and isotonic saline (placebo)infusion. The order of infusion is randomized. An interval of 30 minutes is planned between the two infusions.

Criteria 

Inclusion Criteria:

pressure support ventilation or CPAP
respiratory rate > 35.min-1
respiratory rate/tidal volume > 105

Exclusion Criteria:

vasoactive agents (dopamine lower than 5 mcg.kg-1.min-1 is not considered as vasoactive agent)
body temperature > 38 °C
Glasgow Coma Scale < 9
FIO2 > 0.6
PEEP > 10 cmH2O
pH < 7.30
No Results Posted