Title
Spironolactone and Insulin Resistance in Chronic Heart Failure (CHF)
Effects of Spironolactone on Insulin Resistance in Patients With Chronic Heart Failure
Phase
Phase 4Lead Sponsor
Tottori UniversityStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Chronic Stable Heart FailureIntervention/Treatment
spironolactone furosemide ...Study Participants
16The purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.
Diuretics is useful in CHF patients. On the other hand, they deteriorate glucose metabolism. Therefore, the purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.
spironolactone 25mg/day, 16 weeks and furosemide 20mg/day, 16weeks
Inclusion Criteria: chronic stable heart failure Exclusion Criteria: renal dysfunction or under treatment with antidiabetic agents