Trial | NCT00623142  Report issue

Title

The Protective Effects Of Treatment With Hyperbaric Oxygen Prior To Bypass Heart Surgery
The Effects of Hyperbaric Oxygen Preconditioning On Cardiovascular Protection & Ischemic Reperfusion Injury

  • Phase

    Phase 1/Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    oxygen ...

  • Study Participants

    81
The purpose of this study was to determine if treating patients who have coronary heart disease with hyperbaric oxygen (HBO) prior to coronary artery bypass graft (CABG) surgery reduces injury to the heart and vascular system during and after surgery. Furthermore, this study also aims to identify some of the post CABG clinical effects of HBO treatment prior to CABG.
Study Started
Jan 31
2005
Primary Completion
Jan 31
2007
Study Completion
Jan 31
2008
Last Update
Jul 15
2019

Drug Hyperbaric Oxygen

100% Oxygen at 2.4 ATA for 30 minutes followed by 5 minutes break followed by 100% Oxygen at 2.4 ATA for another 30 minutes. This intervention was given about 4 to 5 hours prior to CABG

  • Other names: Hyperbaric Oxygen Preconditioning

A No Intervention

Patients in this arm were not treated with HBO prior to CABG

B Experimental

Patients in this arm were treated with HBO prior to CABG

Criteria 

Inclusion Criteria:

Patients undergoing elective first time CABG
Patients with at least 1 vessel coronary artery disease undergoing on- pump CABG

Exclusion Criteria:

Age ≤ 20 years or ≥ 85 years
Ejection fraction < 30%
Unstable angina
Recent myocardial infarction (< 1 month)
Any additional cardiac disease (e.g. arrythmia, aneurysm, valvular/septal disease, dissection or elevated pulmonary artery pressure)
Any end stage organ failure (e.g. renal and respiratory failure)
History of chronic obstructive pulmonary disease (COPD)
Pneumothorax
Pulmonary bullae
Convulsions
Current history of malignancy
Severe myopia or intraocular lens
Patients on K+(ATP) Channel Openers e.g. Nicorandil, Oral Hypoglycemics, Opioid Analgesics, Catecholamines.
No Results Posted