Trial | NCT00549536  Report issue

Title

The Effect of Calcium Supplementation on Insulin Resistance and 24h Blood Pressure
The Effect of Oral Calcium Supplementation on Insulin Sensitivity, Intracellular Cationic Concentrations and the Transmembrane Sodium/Hydrogen Exchanger Activity in Subjects With Type 2 Diabetes and Hypertension

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    calcium ...

  • Study Participants

    31
Increased levels of intracellular calcium are thought to diminish maximal cellular response to insulin and induce insulin resistance. Also, both hypertension and diabetes are thought to be conditions of altered intracellular ionic state. The aim of the present study is to investigate the possible effect of oral calcium supplementation on intracellular ions, insulin sensitivity, 24-h blood pressure and sodium/hydrogen exchanger activity in patients with type 2 diabetes and essential hypertension.
Study Started
Jan 31
2007
Primary Completion
May 31
2008
Study Completion
May 31
2008
Last Update
Jul 04
2008
Estimate

Dietary Supplement tablets each containing of 1000mg elemental calcium (Mega-Calcium Sandoz)

1500 mg of elemental calcium per day.

  • Other names: Mega-Calcium Sandoz

2 No Intervention

1 Active Comparator

Patients on calcium supplementation

Criteria 

Inclusion Criteria:

Patients with hypertension, diabetes and the metabolic syndrome (according to the definition of the National Cholesterol Education Program, Adult Panel III (NCEP, ATP III).
Signed the concent form

Exclusion Criteria:

Secondary Hypertension
Stage II or III hypertension
History of renal disease
Sleep apnea
Acute or chronic inflammation
History of coronary artery disease
Heart failure stage III or IV according to the New York Heart Association
Active liver disease
History of malignancy
Parathyroidism
History of kidney stones
Calcium supplement ingestion
Drugs that alter insulin resistance
Treatment with insulin
Alcohol abuse or other conditions with poor prognosis
Treatment with non-inflammatory steroid agents, corticosteroids, or any other treatment that affects blood pressure
No Results Posted