Title
CT-011 MAb in DLBCL Patients Following ASCT
Phase II Safety and Efficacy Study of the Monoclonal Antibody CT-011 in Patients With Diffuse Large B-Cell Lymphoma Following Autologous Stem Cell Transplantation
Phase
Phase 2Lead Sponsor
CureTech LtdStudy Type
InterventionalStatus
Completed Results PostedIntervention/Treatment
pidilizumab ...Study Participants
72Autologous peripheral blood stem cell transplantation combined with high dose chemotherapy is the treatment of choice given to patients with diffuse large-B cell lymphoma (DLBCL) following relapse of the disease. Although many people are cured of their lymphoma with this therapy, the disease comes back in a certain proportion of patients. The purpose of this study is to test the safety and effectiveness of the monoclonal antibody, CT-011, in patients with DLBCL who have received autologous peripheral blood stem cell transplantation. All final eligible patients will receive an IV infusion of CT-011 on Day 1 (30 to 90 days post autologous PBSCT). Treatment will be repeated every 42 days for a total of three courses with treatment visits on Days 1, 43, and 85. Follow-up for safety and clinical outcome will be conducted throughout the study till 18 months post autologous PBSCT. Approximately 70 patients will participate in this study.
IV infusion of 1.5 mg/kg of CT-011 on Day 1(60 to 90 days post autologous PBSCT). Treatment was repeated every 42 days for a total of three courses with treatment visits on Days 1, 43, and 85.
Inclusion Criteria: Patient's age is 18 years or older, both genders. Confirmed Diffuse Large B-cell Lymphoma, transformed follicular lymphoma, diffuse mixed cell lymphoma or primary mediastinal large cell lymphoma with B-cell lineage. The lymphoma is chemosensitive. The lymphoma did not progress since pre-transplant chemotherapy. ECOG performance status 0-1. Exclusion Criteria: Serious other illness. Active autoimmune disease. Type 1 diabetes. Known immune deficiency. Clinical evidence of primary or secondary brain or spinal cord involvement by lymphoma. Active bacterial, fungal, or viral infection. Positive HIV, Hepatitis B surface antigen plus viremia, or Hepatitis C antibody plus viremia. Pregnant or nursing (positive pregnancy test). Other concurrent clinical study or investigational therapy.
| Event Type | Organ System | Event Term | CT-011 Antibody |
|---|
PFS (progression-free survival ) will be determined at the eligible patient populations
